Description
Buy 2-FDCK Fluoroketamine 2'-Fl-2-Oxo-PCM
Buy 2-FDCK Fluoroketamine 2'-Fl-2-Oxo-PCM
2-Fluorodeschloroketamine (also known as
2'-Fl-2-Oxo-PCM,
Fluoroketamine and
2-FDCK) is a
dissociative anesthetic[1] related to
ketamine. Its sale and use as a
designer drug has been reported in various countries.
[2][3][4] It is an analogue of ketamine where the
chlorine group has been replaced by
fluorine. Due to its recent emergence, the pharmacological specifics of the compound are mostly unclear, but effects are reported to be similar to its parent compound, ketamine.
History
The synthesis of 2-FDCK was first described in a 2013 paper as part of a larger effort to synthesize and evaluate new anesthetic drugs based on ketamine and its analogues.
[1] Ketamine itself was first introduced in 1964 and was approved for clinical use in 1970. Since then it has become one of the most important and applicable general anesthetics as well as a popular recreational drug.
The use of 2-FDCK as a research chemical has been reported in various countries.
[2][5][6] Many of these new psychoactive substances (
NPS) appear on the drug market in order to circumvent existing drug policies. 2-FDCK was first formally notified by the
EMCDDA in 2016, alongside 65 other new substances.
[6] Due to its recent appearance, little research has been done on the compound so far.
In January 2023, Israeli Biotech company "Clearmind Medicine Inc." announced the successful completion of a preclinical study examining 2-FDCK in a rat model of depression, with the compound outperforming ketamine in longevity of antidepressant effect
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Fluorodeschloroketamine (also known as 2-Fl-2′-Oxo-PCM, Fluoroketamine and 2-FDCK) is a dissociative anesthetic. It is an analogue of ketamine where the chlorine group has been replaced by fluorine.Buy 2-FDCK online
2-fdck (also named Fluoroketamine) is very similar with MXPP. This product is intended for forensic and research applications.
2F-DCK (2-Fluorodeschloroketamine)
In recent years, the illicit drug market has seen the emergence of new psychoactive substances (NPS), also known as designer drugs, which aim to circumvent existing drug policies. One such substance that has gained attention is 2-Fluorodeschloroketamine (2F-DCK), a dissociative anesthetic closely related to ketamine. This article serves as a comprehensive guide to 2F-DCK, providing insights into its pharmacological properties, toxicokinetic profiles, and potential risks for drug users.
Section 1: Understanding 2F-DCK
- Introduction to 2F-DCK
- Definition and molecular structure
- Pharmacological effects and target receptors
- Similarities and differences with ketamine
- Historical Context
- Discovery and emergence in the drug market
- Reported cases and prevalence
- Legal status and drug scheduling
- Chemical Properties
- Physical appearance and formulation
- Analytical methods for detection and quantification
- Stability and degradation pathways
Section 2: Pharmacokinetic Profiles
- Metabolic Fate
- In vitro and in vivo metabolism studies
- Identification of major metabolites
- Enzymes involved in metabolism
- Toxicokinetic Parameters
- Unbound fraction and protein binding
- Hepatic clearance and in vitro-in vivo extrapolation (IVIVE)
- Comparison with other dissociative ketamine analogues
- Routes of Administration and Absorption
- Oral, intranasal, and intravenous administration
- Absorption kinetics and bioavailability
- Distribution and tissue accumulation
Section 3: Analytical Detection Methods
- Sample Collection and Preparation
- Blood, urine, and hair as matrices
- Extraction techniques and sample storage
- Challenges and limitations in analysis
- Analytical Techniques
- Gas chromatography-mass spectrometry (GC-MS)
- Liquid chromatography-mass spectrometry (LC-MS)
- High-resolution mass spectrometry (HRMS)
- Validation and Quality Control
- Method validation parameters
- Accuracy, precision, and limits of detection
- Quality control measures and reference standards
Section 4: Pharmacological Effects and Adverse Reactions
- Psychoactive Effects
- Dissociative and hallucinogenic properties
- Duration and intensity of effects
- Subjective experiences and user reports
- Potential Risks and Adverse Reactions
- Acute toxicity and overdose symptoms
- Drug interactions and contraindications
- Long-term effects and potential addiction
- Medical and Therapeutic Applications
- Anesthetic and analgesic properties
- Potential for treating psychiatric disorders
- Research and clinical trials
Section 5: Risk Assessment and Harm Reduction
- Public Health Concerns
- Increased prevalence and availability
- Challenges in regulation and control
- Monitoring and surveillance efforts
- Harm Reduction Strategies
- Education and awareness campaigns
- Safer drug use practices
- Access to drug treatment and support services
- International Perspectives and Policies
- Global drug control conventions
- Country-specific responses and legislation
- Collaboration and information sharing
Section 6: Conclusion
In conclusion, 2-Fluorodeschloroketamine (2F-DCK) is a novel psychoactive substance that has gained popularity in the illicit drug market. Understanding its pharmacological properties, toxicokinetic profiles, and potential risks is crucial for public health professionals, law enforcement agencies, and healthcare providers. Further research is needed to fully comprehend the long-term effects and societal impact of this emerging substance. By staying informed and adopting harm reduction strategies, we can mitigate the potential risks associated with 2F-DCK and other designer drugs.
References (Include a list of properly formatted references)
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IUPAC name: 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone
CAS Number: 111982-50-4
Formula: C13H16FNO
Molar mass: 221.28 g·mol−1
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2-Fluorodeschloroketamine (2-FDCK) as a substitute for ketamine has emerged among drug abusers in recent years.
However, 2-FDCK has not been controlled or regulated in many countries, which may be partly related to the lack of evidence on its abuse potential.
In this study, we evaluated the abuse potential of 2-FDCK via the tests of the conditioned place preference (CPP), locomotor sensitization, drug self-administration and drug discrimination using ketamine as a reference.
2-FDCK induced significant CPP at a minimum dose of 3 mg/kg in mice, an effect comparable with that of ketamine (3 mg/kg). Acute injections of 2-FDCK or ketamine at 30 mg/kg enhanced locomotor activity.
Repeated treatments with this dose of 2-FDCK and ketamine induced locomotor sensitization after withdrawal.
2-FDCK readily induced self-administration with 0.5 mg/kg/infusion, the same dose for ketamine, and induced the highest seeking response at 1 mg/kg. Drug discrimination test showed that 2-FDCK dose-dependently substitute for ketamine with comparable ED50 to ketamine in substitution testing.
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Taken together, these results strongly suggested that 2-FDCK has an abuse potential comparable with ketamine.
2-Fl-2′-Oxo-PCM (additionally referred to as 2-Fluorodeschloroketamine, 2-FDCK, and inaccurately as 2-Fluroketamine, Fluoroketamine, and 2-FK) is a lesser-acknowledged novel dissociative substance of the arylcyclohexylamine class. It is chemically just like ketamine and deschloroketamine . It is notion to behave as an NMDA receptor antagonist, despite the fact that studies are presently limited. 2-fdck for sale usa
The origins of 2F-DCK aren’t well-documented. It seems to have first grown to be had on the market on the net studies chemical marketplace in 2017, wherein it become advertised as a prison substitute for ketamine. It become launched after the hit advent of a comparable ketamine analog, deschloroketamine. buy 2-fdck
Subjective consequences consist of sedation, motor management loss, ache relief, inner hallucinations, conceptual thinking, euphoria, and dissociation. Dissociation is a complicated intellectual country characterized via way of means of perceptual distortions and emotions of detachment from the surroundings and one’s self. 2F-DCK’s consequences are stated to be just like the ones of ketamine. 2 fdck for sale
Like ketamine, 2F-DCK’s consequences are noticeably dose-dependent, with decreased doses generating alcohol-like intoxication and better doses generating hallucinogenic out-of-frame states (additionally referred to as a “k-hole”).
Limited statistics exist on the pharmacology, metabolism, or toxicity of 2-FDCK. It has an incredibly short record of human use. It is strongly cautioned to apply damage discount practices if the use of this substance. buy 2-fdck us
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2-Fluorodeschloroketamine, or 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone, is classified as an arylcyclohexylamine drug. Arylcyclohexylamines pills are named for his or her systems which consist of a cyclohexane ring certain to be a fragrant ring alongside an amine group. high purity 2fdck
Buy 2-FDCK online/buy 2 fdck .2-FDCK consists of a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). An amino methyl chain (-N-CH3) is certain to the adjoining alpha carbon of the cyclohexanone ring. Additionally, the phenyl ring is replaced in R2 with a fluorine group. 2-fdck for sale
2-Fluorodescholoroketamine is a chiral molecule and is frequently produced as a racemate. Des- is a prefix utilized in chemistry to indicate the absence of a useful group (in this case “chloro”) consequently 2-FDCK is known for holding a fluorine substitution at its phenyl ring instead of the chlorine that’s observed in ketamine. 2 fdck usa
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- Recreational Use: Recreationally, it is used for its dissociative and mind-altering effects. Please keep in mind, using any substance for recreational purposes can carry potential risks with negative psychological reactions and physical harm.
- Dosage and Administration: The appropriate dosage of 2-FDCK can vary widely depending on individual tolerance and the desired effects. We recommend that you should start with a low dose and gradually increase if necessary. Avoid combining it with alcohol or any other substances.
- Risk of Dependence: Regular or heavy use of these dissociative substances can lead to the development of psychological dependence. Using substances like these responsibly means using them in moderation and paying attention to any signs of becoming dependent.
- Health and Safety: As with any psychoactive substance, there are potential health risks associated with 2-FDCK use. These may include impaired coordination, confusion, hallucinations, and potential accidents or injuries. Individuals with a history of mental health issues should approach its use with caution.
- Legal Status: These substances that are structurally similar to controlled substances may fall under the category of analogs or “designer drugs,” even if they are not explicitly listed as controlled substances. Check our other webs
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The chemical is known for its dissociative effects like its parent compound ketamine.A feeling of detachment can induce from one’s body and surroundings. Also, it can lead them to an altered perception of reality. Users can experience a sense of euphoria and emotional numbing while under the influence of this chemical. This might be attractive to individuals looking for short term relief from symptoms of anxiety or depression. So be careful before looking for
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Many users also report mild to moderate visual and auditory distortions. Changes in how you sense things can add to the special and dreamlike feelings linked with dissociative substances.Besides, research is ongoing into the potential therapeutic applications of the chemical. Some studies suggest, It may have rapid-acting antidepressant effects like ketamine. However, the safety and efficacy of it for such purposes are not yet well-established.
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Ketamine-like 2-fluorodeschloroketamine is a
dissociative anesthetic also known as 2′-Fl-2-Oxo-PCM and
Fluoroketamine or
2-FDCK. Various nations have reported its sale and usage as a designer drug. Fluorine has
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2-FDCK (known as 2-Fluorodeschloroketamine) is a dissociative substance of the arylcycohexylamine class.
Other examples in this class include PCP and ketamine,
buy 2-FDCK online is more closely related to ketamine and is
reported to have many similar effects. Created originally as a legal replacement for ketamine sometime around
2013, 2-FDCK first began being sold primarily through the online chemical research market in 2018 Despite
there being very few formal studies or clinical trials researching
purchase 2-FDCK online, there are countless first-hand reports
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Due to its similarities to ketamine (as well as its legality), 2-FDCK has become an extremely popular
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longer “trip” duration compared to that of ketamine, despite dosages being roughly on par (Psychonaut Wiki
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