Description

Buy 4-Chloromethcathinone Cas 1225843-86-6

Buy 4-Chloromethcathinone (also known as 4-CMC and clephedrone) is a stimulant drug of the cathinone class that has been sold online as a designer drug.^[1][2] 4-CMC produces similar effects to mephedrone, and has been sold as an alternative in countries where mephedrone was scheduled. 4-CMC produces similar side effects to mephedrone, including: increased blood pressure, tachycardia, hyperthermia, and anxiety.^[3] Its chemical structure closely resembles para-chloromethamphetamine, raising concerns about its potential to readily induce cell death of serotonergic neurons. However, no neurotoxicity of this kind has been found to occur, but studies involving mice do indicate that it is neurotoxic through other mechanisms, similarly to other cathinones. 4-CMC is cytotoxic and induces oxidative stress, more so than 4-MMC.^[4] 4-CMC mainly acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA), and partially as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with similar potency to mephedrone^[3]

Effects of 4-CMC and mephedrone on neurotransmitter release^[3]

Drug	Release at DATEC50 (nM)	Release at NETEC50 (nM)	Release at SERTEC50 (nM)
Mephedrone (4-MMC)	103 ± 16	83 ± 20	188 ± 22
4-CMC	91 ± 11	99 ± 18	169 ± 20

Effects of 4-CMC and mephedrone on inhibition of neurotransmitter uptake^[3]

Drug	Uptake Inhibition at DATIC50 (nM)	Uptake Inhibition at NETIC50 (nM)	Uptake Inhibition at SERTIC50 (nM)
Mephedrone (4-MMC)	769 ± 106	319 ± 40	600 ± 99
4-CMC	1014 ± 78	559 ± 57	542 ± 38

4-CMC is an Anlage I controlled drug in Germany. Sweden's public health agency suggested classifying 4-Chloromethcathinone (klefedron) as illegal narcotic on June 1, 2015.^[5] As of October 2015, 4-CMC is a controlled substance in China.^[6] 4-CMC is considered a Schedule 1 substance in Virginia.^[7] In December 2019, the UNODC announced scheduling recommendations placing 4-CMC into Schedule II.^[8]