Buy para-Iodoamphetamine (PIA) Cas 21894-72-4

para-Iodoamphetamine (PIA), also known as 4-iodoamphetamine (4-IA), is a monoamine releasing agent (MRA) and serotonergic neurotoxin of the amphetamine family related to para-chloroamphetamine (PCA).^[1] PIA acts as a serotonin releasing agent (SRA).^[2] In animal drug discrimination tests, PIA fully substitutes for MDMA and (+)-MBDB.^[1] It also has very low affinity for certain serotonin receptors, including the serotonin 5-HT₁ receptor (K_i = 7,660 nM) and the serotonin 5-HT₂ receptor (K_i = 43,000 nM).^[3] PIA has been described as having either similar serotonergic neurotoxicity as PCA^[1] or as having much weaker serotonergic neurotoxicity than PCA.^[2][4] PIA, also known as 4-iodoamphetamine, is a phenethylamine and amphetamine derivative and a para-halogenated amphetamine. PIA is closely related to other para-halogenated amphetamines such as PCA, para-bromoamphetamine (PBA), and para-fluoroamphetamine (PFA). Iofetamine, also known as N-isopropyl-(¹²³I)-para-iodoamphetamine, is a derivative of PIA used as a radiopharmaceutical and diagnostic agent.^[5] 5-Iodo-2-aminoindane (5-IAI), the 2-aminoindane analogue of PIA, was an attempt to make a non-neurotoxic analogue of PIA that proved to be less neurotoxic.^[1]