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4-Methylmethamphetamine (4-MMA), also known as mephedrine, is a putative stimulant and entactogen drug of the amphetamine family. It acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA).^[1][2] The drug is the β-deketo analogue of mephedrone (4-methylmethcathinone; 4-MMC) and the N-methyl analogue of 4-methylamphetamine (4-MA).^[3][4] 4-MMA acts as a potent and well-balanced serotonin–norepinephrine–dopamine releasing agent (SNDRA).^[1][2] It induces hyperlocomotion and stereotypy (psychostimulant-like effects) as well as hyperthermia in mice, similarly to methcathinone.^[5][6]

Monoamine release of 4-methylmethamphetamine and related agents (EC₅₀Tooltip Half maximal effective concentration, nM)

Compound	NETooltip Norepinephrine	DATooltip Dopamine	5-HTTooltip Serotonin	Ref
Dextroamphetamine	6.6–10.2	5.8–24.8	698–1,765	[7][8][9][10]
Dextromethamphetamine	12.3–14.3	8.5–40.4	736–1,292	[7][11][9][10]
4-Methylamphetamine	22.2	44.1	53.4	[12][13][9]
4-Methylmethamphetamine (mephedrine)	66.9	41.3	67.4	[1][2]
4-Methylethylamphetamine	182	550	102	[1]
4-Methylpropylamphetamine	752	IA	650	[1]
4-Methylbutylamphetamine	IA	IA	IA	[1]
4-Methylmethcathinone (mephedrone)	58–62.7	49.1–51	118.3–122	[11][8][14][15][16]
Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs: [17][18]

In contrast to methamphetamine and methcathinone, 4-MMA appears to produce minimal dopaminergic neurotoxicity in mice.^[5][6] Conversely, mephedrone shows no dopaminergic neurotoxicity at all in mice.^[5][6] It was theorized that 4-methyl and β-keto substitutions on amphetamines may result in loss of activity at the vesicular monoamine transporter 2 (VMAT2), loss of elevations of cytosolic dopamine concentrations, and consequent loss of dopaminergic neurotoxic potential.^[5][6] Accordingly, the dopaminergic neurotoxicity of 4-MMA was greatly enhanced by the dopamine precursor levodopa (L-DOPA), the monoamine oxidase inhibitor (MAOI) pargyline, and methamphetamine (a VMAT2 inhibitor/reverser), all of which are known to increase the cytosolic pool of dopamine.^[6] However, in contrast to 4-MMA, the dopaminergic neurotoxicity of methcathinone was enhanced only by levodopa and of mephedrone was enhanced only by methamphetamine.^[6]

• Substituted amphetamine
• 3-Methylmethamphetamine (3-MMA)
• 3-Methoxymethamphetamine (MMMA)
• 4-Methoxymethamphetamine (PMMA)
• 4-Fluoromethamphetamine (4-FMA)
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  Information regarding the purchase of 4-Methylmethamphetamine (4-MMA) cannot be provided. This substance is a stimulant and entactogen structurally related to controlled substances. The acquisition, possession, and use of such chemicals are strictly regulated by law in most jurisdictions due to significant health risks and the potential for abuse. For information on chemical regulations or substance safety, consulting official government health and drug enforcement agencies is recommended.

   

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    4-Methylmethamphetamine (4-MMA), also known as mephedrine, is a putative stimulant and entactogen drug of the amphetamine family. ...

    

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    4-Methylmethamphetamine. Ngôn ngữ; Đang tải… Tải về PDF; Theo dõi · Sửa đổi. 4-Methylmethamphetamine (4-MMA) là một chất giả định ...

    

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