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Buy Corbadrine (Neo-Cobefrin) Cas 829-74-3

Corbadrine, sold under the brand name Neo-Cobefrine and also known as levonordefrin and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States.^[1][2][3] It is usually used in a pre-mixed solution with local anesthetics, such as mepivacaine.^[4] The drug acts as a non-selective agonist of the α₁-, α₂-, and β-adrenergic receptors.^[5][6][7] It is said to have preferential activity at the α₂-adrenergic receptor.^[5][7] Corbadrine is also a metabolite of the antihypertensive drug methyldopa and plays a role in its pharmacology and effects.^[8] Corbadrine is metabolized primarily by catechol O-methyltransferase (COMT).^[7] Corbadrine, also known as 3,4,β-trihydroxy-α-methylphenethylamine or as 3,4,β-trihydroxyamphetamine, as well as α-methylnorepinephrine or (–)-3,4-dihydroxynorephedrine, is a substituted phenethylamine and amphetamine derivative.^[1][3] Analogues of corbadrine include α-methyldopamine, dioxifedrine (3,4-dihydroxyephedrine; α-methylepinephrine), dioxethedrin (3,4-dihydroxy-N-ethylnorephedrine; α-methyl-N-ethylnorepinephrine), and hydroxyamphetamine (4-hydroxyamphetamine; α-methyltyramine). Corbadrine is the generic name of the drug and its INNTooltip International Nonproprietary Name.^[1][3][2] It is also known as levonordefrin, which is its USANTooltip United States Adopted Name.^[1][3][2] Synonyms of corbadrine include α-methylnorepinephrine and (–)-3,4-dihydroxynorephedrine.^[9] The drug has been sold under the brand name Neo-Cobefrine