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Buy Ritodrine Cas 26652-09-5
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Buy Ritodrine Cas 26652-09-5

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Description

Buy Ritodrine Cas 26652-09-5

Ritodrine, formerly sold under the brand name Yutopar among others, is a tocolytic drug used to stop premature labor.[2][3] It was withdrawn from the US market, according to the FDA Orange Book. It was available in oral tablets or as an injection and was typically used as the hydrochloride salt. The drug acts as a selective β2-adrenergic receptor agonist.[4] It was first approved for medical use in the United States in 1984.[5]

Medical uses

Ritodrine is used to treat preterm labor.[2]

Contraindications

Possible contraindications of ritodrine include type 2 diabetes, high blood pressure, and migraines.

Side effects

Most side effects of β2-adrenergic receptor agonists result from their concurrent β1-adrenergic receptor agonistic activity, and include increase in heart rate, rise in systolic blood pressure, decrease in diastolic blood pressure, chest pain secondary to myocardial infarction, and arrhythmia. β-Adrenergic receptor agonists may also cause fluid retention secondary to decrease in water clearance, which when added to the tachycardia and increased myocardial work, may result in heart failure. In addition, they increase gluconeogenesis in the liver and muscle resulting in hyperglycemia, which increases insulin requirements in diabetic patients. The passage of β-adrenergic receptor agonists through the placenta does occur and may be responsible for fetal tachycardia, as well as hypoglycemia or hyperglycemia at birth. It has also been associated with postpartum bleeding.[citation needed] Ritodrine has been reported rarely to cause serious side effects including rhabdomyolysis, hepatotoxicity, leukopenia, pulmonary edema, and psychiatric symptoms, among others.[6][7][8][9][10]

Pharmacology

Pharmacodynamics

Ritodrine is a short-acting β2-adrenergic receptor agonist – a class of medication used for smooth muscle relaxation (other similar drugs are used in asthma or other pulmonary diseases such as salbutamol [albuterol]). Since ritodrine has a bulky N-substituent, it has high β2-adrenergic receptor selectivity. Also, the 4-hydroxy group on the benzene ring is important for activity as it is needed to form hydrogen bonds. Since the drug is β2-selective, it is used for premature labor.[11]

Pharmacokinetics

The 4-hydroxy group of ritodrine makes it susceptible to metabolism by catechol-O-methyl transferase (COMT).

Chemistry

Ritodrine, also known as 4-hydroxy-β-hydroxy-N-(4-hydroxyphenylethyl)amphetamine or as N-(4-hydroxyphenylethyl)-4-hydroxynorephedrine, is a substituted phenethylamine and amphetamine derivative.[12][13][14] The experimental log P of ritodrine is 2.4 and its predicted ranges from 1.53 to 2.3.[12][13][14]

History

Ritodrine was first approved for medical use in the United States in 1984.[5]

Society and culture

Names

Ritodrine is the generic name of the drug and its INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, BANTooltip British Approved Name, and DCFTooltip Dénomination Commune Française.[15][16] In the case of the hydrochloride salt, its generic name is ritodrine hydrochloride and this is its USANTooltip United States Adopted Name and BANMTooltip British Approved Name.[15][16] It is also known by its developmental code name DU-21220.[15] The drug has been sold under brand names including Pre-Par, Utopar, and Yutopar, among others.[15][16]

See also

  • Hexoprenaline
  • Isoxsuprine
  • Terbutaline
  • Bedoradrine
  • AI Overview
    Ritodrine (CAS 26652-09-5) is a β-adrenergic agonist and uterine relaxant available for research purposes,
    commonly supplied as Ritodrine hydrochloride (CAS 23239-51-2) from chemical suppliers like MedChemExpress and LGC Standards. It is used for studying the arrest of premature labor, primarily marketed for in vitro or animal research rather than human clinical use. 
    MedchemExpress.com +2
    Where to Buy (Research Grade):
    • MedChemExpress (MCE): Offers high-purity Ritodrine (DU21220) for scientific research.
    • LGC Standards/TRC: Supplies Ritodrine Hydrochloride for pharmaceutical testing and research.
    • Biosynth: Provides Ritodrine HCl (BR164351).
    • TargetMol/Biorbyt: Offer Ritodrine-d4 (deuterated) and Ritodrine hydrochloride for laboratory use. 
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    Important Information:
    • Usage: For research only; not for human consumption or pharmaceutical use by patients.
    • Context: Ritodrine was historically used to stop premature labor but has been withdrawn from the market in many regions due to safety concerns.
    • Related Compound: Ritodrine Hydrochloride (CAS 23239-51-2) is the common active salt form found in chemical catalogs. 
      MedchemExpress.com +4
    Ensure you review the manufacturer's safety data sheet (SDS) before purchase. 
    • Ritodrine (DU21220) | β-Adrenergic Agonist | MedChemExpress
      Ritodrine (Synonyms: DU21220) ... Ritodrine (DU21220) is a β-adrenergic agonist, also an effective smooth muscle and uterine relax...
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    CAS 26652-09-5 (RitodrineHydrochloride)

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    CAS 23239-51-2: Ritodrine hydrochloride

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    Ritodrine hydrochloride is a synthetic beta-adrenergic agonist primarily used as a tocolytic agent to inhibit premature labor by relaxing uterine ...Read more

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