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Oxyfedrine, sold under the brand names Ildamen and Myofedrin among others, is a sympathomimetic agent and coronary vasodilator which is used in the treatment of coronary heart disease, angina pectoris, and acute myocardial infarction.^{[1][3][4][5][6][7]} It is taken by mouth or intravenously.^[1] The drug acts as a β-adrenergic receptor partial agonist.^[1][7] It may also act as a norepinephrine releasing agent via its major active metabolite norephedrine.^[2] Oxyfedrine is a phenethylamine and amphetamine derivative.^[6][7] Oxyfedrine has been marketed in Europe, Hong Kong, India, Central America, and elsewhere.^[4][8][9] It appears to remain marketed only in India.^[9] Oxyfedrine is a β-adrenergic receptor partial agonist.^[1][7] It appears to be non-selective for the β₁- and β₂-adrenergic receptors.^[7] It is selective for the β-adrenergic receptors over the α-adrenergic receptors.^[7] However, it has also been reported to interact with the α-adrenergic receptors at high concentrations, acting as a partial agonist or antagonist of these receptors.^[7] Norephedrine, a norepinephrine releasing agent, is a major active metabolite of oxyfedrine, and hence oxyfedrine may additionally act as an indirectly acting sympathomimetic.^[2] It has been found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotropic effects,^[1] thereby not precipitating angina pectoris. The latter property (positive chronotropic and inotropic effects) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon.^{[additional citation(s) needed]} The drug is chemically and pharmacologically unrelated to any other antianginal drugs.^[1] Oxyfedrine's oral bioavailability is 85%.^[1] The plasma protein binding is almost 100%.^[1] Its elimination half-life is 4.2 hours.^[1] Norephedrine is a major active metabolite of oxyfedrine.^[2] The excretion of the active metabolites of oxyfedrine is 90% in urine.^[1] About 75 to 100% of oxyfedrine is excreted as norephedrine.^[2] Oxyfedrine is a substituted phenethylamine and amphetamine derivative.^[7] It is l-norephedrine with a bulky and lipophilic 3-methoxypropiophenone substituent at the nitrogen atom.^[7] Mannich condensation of phenylpropanolamine (1) with formaldehyde and m-acetanisole (3-acetylanisole) (2) yields oxyfedrine (3).^[10]

Synergistic effects of oxyfedrine with antibiotics against bacteria have been suggested.^[11]