Description

Buy 4-Fluoroephedrine (4-FEP) Cas 63009-92-7

4-Fluoroephedrine (4-FEP) is a "novel psychoactive substance" and substituted β-hydroxyamphetamine derivative related to ephedrine.^[1][2][3] Similarly to other amphetamines, 4-fluoroephedrine acts as a monoamine reuptake inhibitor and monoamine releasing agent.^[3][4] It specifically acts as a selective norepinephrine releasing agent.^[3][4] In contrast to many other amphetamines, but similarly to most cathinones, 4-fluoroephedrine lacks affinity for the human trace amine-associated receptor 1 (hTAAR1).^[3][4][5] 4-Fluoroephedrine, also known as 4-fluoro-β-hydroxy-N-methylamphetamine, is a substituted phenethylamine, amphetamine, and β-hydroxyamphetamine derivative.^[6][1] It is the 4-fluoro analogue of ephedrine.^[6][1] The synthesis of 4-fluoroephedrine has been described.^[7] It can serve as a precursor in the synthesis of 4-fluoromethamphetamine (4-FMA).^[3] The predicted log P (XLogP3) of 4-fluoroephedrine is 1.0.^[6] For comparison, the predicted log P of ephedrine is 0.9.^[8] 4-Fluoroephedrine was first described in the scientific literature by 1991.^[7] The next mention of it in the literature was in 2013, when it was identified as a "novel psychoactive substance".^[9] The pharmacology of 4-fluoroephedrine was characterized in 2015.^[3][4] 4-Fluoroephedrine is known to be a metabolite of 4-fluoromethcathinone (4-FMC; flephedron