MDTFEA, also known as 3,4-methylenedioxy-N-(2,2,2-trifluoroethyl)amphetamine, is a chemical compound and possible psychoactive drug of the phenethylamine, amphetamine, and MDxx families related to the entactogenMDEA.[1][2][3] It is the derivative of MDEA in which the ethyl group on the amine has been replaced with a trifluoroethyl group.[1][2][3]Alexander Shulgin briefly described MDTFEA in his book PiHKAL (Phenethylamines I Have Known and Loved).[1][3] Based on personal communication to Shulgin, it was described as "possibly active".[1] The drug was tested at a highest total dose of 500mg orally, which was given in three divided doses over a period of 5 or 6hours.[1][2][3] The effects included only a very mild intoxication and little or no sympathomimetic effects, with these possible effects being short-lasting.[1] For comparison, MDEA has a listed dose of 100 to 200mg orally and a duration of 3 to 5hours.[1][2][3]Daniel Trachsel has said that MDTFEA seems to be inactive.[2][3]
The chemical synthesis of MDTFEA has been described.[1]
MDTFEA was first described in the scientific literature by Shulgin in PiHKAL in 1991.[1] It was not synthesized or tested by Shulgin but was instead described to him via personal communication.[1]
Methyl difluoroacetate (CAS 433-53-4) is available from several major chemical suppliers, often listed as Methyl 2,2-difluoroacetate or by its abbreviation MDTFEA
Thermo Scientific Chemicals/Alfa Aesar: Offers 98% purity (Catalog number B22197.14).
TCI Chemicals: Lists 5G and 25G sizes with >97.0%(GC) purity.
Santa Cruz Biotechnology: Provides CAS 433-53-4 for research purposes.
Chem-Impex: Lists the product, likely for intermediate applications.
1PlusChem LLC: Lists 97% purity.
Santa Cruz Biotechnology +7
Product Information
Formula:
Molecular Weight: 110.06 g/mol
Properties: Colorless to almost colorless liquid, boiling point 85-86°C.
Hazard: Highly flammable liquid and vapor. Causes severe skin burns and serious eye damage.
Applications: Used as a building block in chemical synthesis, pharmaceuticals, and as an electrolyte component to improve the thermal stability of lithium-ion batteries.
Sigma-Aldrich +5
Note: Availability and pricing (e.g., ~₹2,600-7,700 for TCI in India, $21+ for 1PlusChem) can vary by supplier and quantity.
Buy Methyl difluoroacetate (CAS 433-53-4), a product for proteomics research, from Santa Cruz. Molecular Formula: F2CHCO2CH3, Molecular Weight: 110.06.
Description. CAS: 433-53-4 | C3H4F2O2 | 110.06 g/mol. A methyl difluoroacetate (MFA)-based LiPF6 solution was applied as an electrolyte to improve the thermal ...Read more
€52.90
Methyl difluoroacetate 96 433-53-4
Sigma-Aldrich
https://www.sigmaaldrich.com › product › aldrich
Linear Formula: F2CHCO2CH ; CAS Number: 433-53-4 ; Molecular Weight: 110.06 ; NACRES: NA.22 ; PubChem Substance ID: 24857822.Read more
Methyl difluoroacetate (CAS 433-53-4) is a key intermediate in pharmaceuticals and agrochemicals, valued for its reactivity and ability to enhance product ...
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