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Buy α-Pyrrolidinoisohexanophenone Cas 2181620-71-1
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Buy α-Pyrrolidinoisohexanophenone Cas 2181620-71-1

Description

Buy α-Pyrrolidinoisohexanophenone Cas 2181620-71-1

α-Pyrrolidinoisohexanophenone (mainly known as A-PiHP or α-PiHP) is a stimulant drug of the cathinone class that has been sold online as a designer drug. It acts as a potent norepinephrine-dopamine reuptake inhibitor (NDRI). In July 2016 α-PiHP was first identified as a designer drug[2] when it was reported to the EUDA by a forensic laboratory in Slovenia.[3][4] It is a positional isomer of pyrovalerone, with the methyl group shifted from the 4-position of the aromatic ring to the 4-position of the acyl chain. Similarly to other cathinones, use of α-PiHP can result in compulsive redosing, addiction, anxiety, paranoia, and psychosis.

Pharmacology

In a classic 2006 study of pyrrolidinyl cathinone derivatives by Meltzer et al. at Organix, the alpha-isobutyl derivative of pyrovalerone, O-2494, was found to have the highest potency in vitro as an inhibitor of the dopamine transporter of the alpha substituted derivatives tested.[5] Compared to α-PVP and α-PHP, α-PiHP displays a higher selectivity for the dopamine transporter.

See also

  • 3F-PiHP
  • Aletamine
  • α-PHP
  • α-PCYP
  • Solriamfetol
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