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Buy βk-5-MAPB Cas 2855950-94-4
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Buy βk-5-MAPB Cas 2855950-94-4

Description

Buy βk-5-MAPB Cas 2855950-94-4

βk-5-MAPB, or BK-5-MAPB, is an entactogen of the benzofuran and cathinone groups which is related to both 5-MAPB and methylone. It was patented by Matthew Baggott and Tactogen and is under investigation by Tactogen for potential medical use.[1][2][3][4]

Pharmacology

Pharmacodynamics

βk-5-MAPB acts as a monoamine releaser with selectivity for serotonin and has a similar potency to MDMA.[1][2][5][3][6] In terms of monoamine release, (S)-βk-5-MAPB has shown a DATTooltip dopamine transporter/SERTTooltip serotonin transporter ratio of 0.6 and a DAT/NETTooltip norepinephrine transporter ratio of 2.7, while (R)-βk-5-MAPB has shown a DAT/SERT ratio of 18 and a DAT/NET ratio of 1.9.[3] In addition, βk-5-MAPB, unlike MDMA, is a potent serotonin 5-HT1B receptor agonist.[7] In rodent drug discrimination tests, (S)-βk-5-MAPB fully substitutes for MDMA whereas (R)-βk-5-MAPB partially substitutes for MDMA and dextroamphetamine at different doses, (R)-βk-5-MAPB and (S)-βk-5-MAPB both generalize to dextroamphetamine, and (S)-βk-5-MAPB but not (R)-βk-5-MAPB substitutes for DOM.[4] Hence, (S)-βk-5-MAPB shows entactogen-, psychedelic-, and stimulant-like effects, whereas (R)-βk-5-MAPB shows more stimulant-like effects, some entactogen-like effects, and no psychedelic-like effects.[4] In other tests, both (S)-βk-5-MAPB and (R)-βk-5-MAPB showed stimulant-like pro-impulsive effects, but (S)-βk-5-MAPB was more potent than (R)-βk-5-MAPB.[8]

See also

  • Substituted benzofuran
  • Substituted cathinone
  • βk-6-MAPB5-MAPB, and 6-MAPB
  • TACT411 and TACT833
  • BK-5-MAPBT
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