Description

Buy 3-Chloro-N-cyclopropylcathinone (3Cl-CpC) Cas 1193779-70-2

3-Chloro-N-cyclopropylcathinone (3Cl-CpC; code names PAL-433, RTI-6037-39) is a stimulant and hybrid monoamine releasing agent and monoamine reuptake inhibitor of the cathinone family related to bupropion (3-chloro-N-tert-butylcathinone).^[1][2][3] It acts specifically as a dual serotonin releasing agent (SRA) and serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI).^[1][2][3] Its EC₅₀Tooltip half-maximal effective concentration for induction of serotonin release is 1,328 nM, whereas its IC₅₀Tooltip half-maximal inhibitory concentration values for monoamine reuptake inhibition are 265 to 533 nM for dopamine, 2,150 nM for norepinephrine, and 3,180 nM for serotonin.^[1][2][3] The drug produces psychostimulant-like effects in animals, with a slow onset of action and a long duration of action.^[1][3] The activities of the individual enantiomers of 3Cl-CpC, (−)-3Cl-CpC (PAL-1122) and (+)-3Cl-CpC (PAL-1123), have also been reported.^[2] 3Cl-CpC was first described in the scientific literature by 2009.^[1][2][3] It was being investigated by the National Institute on Drug Abuse (NIDA) as a potential treatment of stimulant dependence, including cocaine dependence specifically.^[1][2][3]

• 3-Chlorocathinone
• 3-Chloromethcathinone