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Amfecloral (INN) or amphecloral (USAN) is a combination drug containing a central nervous system (CNS) stimulant and anorectic drug, dextroamphetamine, as well as a CNS depressant and sedative-hypnotic, chloral hydrate. Widely used for its anorectic properties, amfecloral was approved by the United States Food and Drug Administration as an anti-obesity drug and marketed and distributed under the brand name Acutran. Upon 1962 passage of the Kefauver-Harris Amendment, pressure grew to withdraw the product from the market, and in 1973, production ceased for Acutran and its generic formulation, concurrent with similar combination anorectics, Desbutal (methamphetamine-pentobarbital) and Obetrol (methamphetamine-dextroamphetamine). The British Pharmacopoeia Commission approved the name amfecloral in 1970.^[2] It is classified as a combination drug constituting active ingredients belong to the phenethylamine and ethanol chemical classes, similar to many combination drugs in widespread use at the time for various indications, including Desbutal, Dexamyl (also branded AmoDex), and Obetrol. Amfecloral belongs to the phenethylamine and substituted amphetamine chemical classes. The raw ingredients used in manufacturing it were dextroamphetamine and chloral hydrate.^[3] Upon ingestion and metabolization, amfecloral is metabolized as dextroamphetamine and chloral hydrate, as well as converting into levoamphetamine, the R enantiomer of amphetamine.^[4] Amphetamine is a stimulant, whereas chloral hydrate is a sedative/hypnotic drug.^[5] The extent of metabolism and in-vivo contribution of a chloral hydrate metabolism to its purported "little to no stimulant activity" is unknown.^{[citation needed]} Acutran was one of several brands, amfecloral one of several formulations distributed as anorectic combination drugs comprising a CNS stimulant and a CNS depressant–respectively known as "uppers" and "downers" in common parlance, conjoined in the form of one pill: others included Desbutal (methamphetamine-pentobarbital) and Obetrol (meth-dexamphetamine), both of which were discontinued concurrent to Acutran in 1973; Eskatrol (amphetamine and the neuroleptic compazine, discontinued 1981), in addition to Dexamyl (dextamphetamine-amylbarbitone).^[1] A review from 1970 specified that amfecloral was unique among amphetamine-like substances in that it displayed little to no stimulant activity, likely due to the powerful sedating effects of chloral hydrate, the same claims were not made of the other combination medications.^[6] The extent of metabolism and in-vivo contribution of a chloral hydrate metabolism to its purported "little to no stimulant activity" is unknown.^{[citation needed]} Following increased scrutiny of combination medications comprising psychostimulant and sedative components with the 1962 passage of the Kefauver-Harris Amendment, then the Controlled Substances Act of 1970, Acutran was withdrawn from the U.S. pharmaceutical market and ceased production, alongside Desbutal (methamphetamine-pentobarbital) and Obetrol (methamphetamine-dextroamphetamine), all three of which were fully discontinued by the end of 1973.

• Amfetaminil
• Clobenzorex
• Desbutal (also discontinued 1973)
• Dexamyl
• Eskatrol
• Obetrol (also discontinued 1973)

• 4-[4-(3-Methyl-4-nitrophenoxy)butoxy]benzonitrile

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  Amfecloral is a member of amphetamines. Amfecloral is a stimulant drug of the phenethylamine and amphetamine chemical classes. For a short period of time, it ...
  AI Overview

  Amfecloral (CAS 5581-35-1) is a combination drug containing dextroamphetamine, acting as a CNS stimulant and anorectic

  . It is a controlled substance regulated under amphetamine-related laws due to its stimulant properties. It cannot be purchased through standard retail channels. Check local regulations for controlled substances. 

  Wikipedia

  • Availability: Due to its nature as a controlled substance, procurement is restricted to licensed manufacturers, researchers, or pharmaceutical suppliers with appropriate regulatory authorization.
  • Safety Warning: It is an anorectic agent (appetite suppressant) and a stimulant. 

  Disclaimer: This information is for educational purposes only. Buying controlled substances without proper authorization is illegal.

  Amfecloral - Wikipedia

  Amfecloral (INN) or amphecloral (USAN) is a combination drug containing a central nervous system (CNS) stimulant and anorectic dru...

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  National Institutes of Health (.gov)

  https://pubchem.ncbi.nlm.nih.gov › Amfecloral

  Amfecloral is a stimulant drug of the phenethylamine and amphetamine chemical classes. For a short period of time, it was available under the brand Acutran.Read more

  Amfecloral: Uses, Interactions, Mechanism of Action

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  8 Oct 2013 — Amfecloral is a stimulant drug of the phenethylamine and amphetamine chemical classes. For a ... CAS number: 5581-35-1. InChI Key: VBZDETYCYXPOAK- ...Read more

  Amfecloral

  Wikipedia

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  Amfecloral (INN) or amphecloral (USAN) is a combination drug containing a central nervous system (CNS) stimulant and anorectic drug, dextroamphetamineRead more

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  ... cas 6chdant, des Accords commerciaux plurilat~raux, les. Membres conviennent ... 5581-35-1 amfecloral (INN). 292520. 3459-96-9 amicarbalide (INN). 292520.Read more

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  Commission Regulation (EC) No 1549/2006 of 17 October ...

  Legislation.gov.uk

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  ... 5581-35-1, amfecloral. 5879-67-4, oletimol. 6443-40-9, xylamidine tosilate. 6903 ... CAS RN. 2925.29, arginine. 2922.42, glutamic acid, arginine L-glutamate ...Read more
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  Amfecloral API Tedarikçileri - Tümünü Bul GMP Üreticiler

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  Amfecloral | CAS No: 5581-35-1 | GMP- sertifikalı tedarikçiler. İştah kesici görevi gören, uyarıcı ve yatıştırıcı etkileri birleştiren, öncelikle kilo ...Read more

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  amfecloral Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |. Stem definition, Drug id, CAS RN. 5113, 5581-35-1. Description ...Read more

  pharmaceutical appendix to the tariff schedule

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  Get the benefits of our premium plans now at a special price for a short time only ... Product CAS No. ... AMFECLORAL 5581-35-1<br />. AMFENAC 51579-82-9<br ...