Description
Buy Buphedrone Cas 408332-79-6
Buphedrone, also known as
β-keto-N-methylphenylisobutylamine, is a
stimulant of the
phenethylamine and
cathinone chemical classes that was first
synthesized in 1928.
[1] It is a synthetic analogue of
cathinone, a stimulant naturally occurring in the
khat plant. Like many other synthetic cathinones (
e.g. mephedrone), it is also found in so called "legal highs" (sometimes also called "bath salts"), a class of designer drugs used to bypass legal restrictions.
[2]
Pharmacology
Buphedrone is a
substituted cathinone, and more broadly related, a
substituted amphetamine and
substituted phenethylamine and, as such, operates as a
norepinephrine-dopamine releasing agent, similar to many of the drugs in its chemical class(es). It mediates this action by reversing the
VMAT2, causing an efflux of the
monoamines; dopamine, norepinephrine, and, to a lesser extent, serotonin.
Chemistry
Buphedrone is a β-ketone and is related to the naturally occurring compounds
cathinone and
cathine. It is also related to
methamphetamine, differing by the β-
ketone substituent (at the β-carbon) and an
ethyl group replacing the
methyl group at the carbon at the α-position relative to the
amine. Another name for buphedrone is phenylacetoethyl-methylamine.
Buphedrone as free base is very unstable; it is prone to dimerization like other α-amino ketones. Because of this, it is sold as various salts, with a
hydrochloride being most common.
Effects
Buphedrone
increases spontaneous rodent locomotor activity,
[3] potentiates the release of
dopamine from
dopaminergic nerve terminals in the
brain,
[4] and causes
appetite suppression. It also causes a possibly dangerous effect of decreasing subjective feeling of thirst. Though the specific effects and toxicity of buphedrone are not well studied,
[5] in general it is expected to have overlapping effects with other synthetic cathinones.
[6]
Legal status
As of October 2015, buphedrone is a controlled substance in China.
[7]
Buphedrone is an
Anlage II controlled drug in Germany.
In the United States, buphedrone is considered a schedule 1 controlled substance as a positional isomer of
mephedrone.
[8]
See also
- Pentedrone
- 4-Methylbuphedrone
- 4-Methylpentedrone
-
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CAS Number. Freebase:
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Buphedrone
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Buphedrone, also known as β-keto-N-methylphenylisobutylamine,
is a stimulant of the phenethylamine and cathinone chemical classes that was first synthesized ...
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