Dexfenfluramine, formerly sold under the brand name Redux, is a serotonergic drug that was used as an appetite suppressant to promote weight loss.[2] It is the d-enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating effects.
Dexfenfluramine was, for some years in the mid-1990s, approved by the United States Food and Drug Administration (FDA) for the purposes of weight loss. However, following multiple concerns about its cardiovascular side effects,[2] the FDA withdrew the approval in 1997.[3] After it was removed in the US, dexfenfluramine was also pulled out in other global markets. It was later superseded by sibutramine, which, although initially considered a safer alternative to both dexfenfluramine and fenfluramine,[4][5][6] was likewise removed from the US market in 2010.[7][8]
The drug was developed by Interneuron Pharmaceuticals, a company co-founded by Richard Wurtman, aimed at marketing discoveries by Massachusetts Institute of Technology scientists.[9] Interneuron licensed the patent to Wyeth-Ayerst Laboratories.[10] Although at the time of its release, some optimism prevailed that it might herald a new approach,[11] there remained some reservations amongst neurologists, twenty-two of whom petitioned the FDA to delay approval.[citation needed] Their concern was based on the work of George A. Ricaurte, whose techniques and conclusions were later questioned.[12]
Dexfenfluramine (Redux), with CAS number 3239-44-9 (or 3239-45-0 for the hydrochloride form), was withdrawn worldwide in 1997 due to reports of valvular heart defects and is considered a toxic compound
. As a result, it is not available for human consumption or conventional purchase.
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Safety and Legal Status:
Medical Risks: Clinical studies linked the use of this substance to serious health conditions, including primary pulmonary hypertension and cardiac valvular disease. These risks led to its removal from the pharmaceutical market to protect public health.
Regulatory Control: Because of its history and pharmacological effects, dexfenfluramine is classified as a controlled substance in many jurisdictions. Unauthorized possession or distribution can carry significant legal penalties.
Restricted Access: This compound is not approved for distribution to the general public. It is generally restricted to licensed scientific institutions for specific laboratory applications or as a reference standard in forensic or chemical analysis. It is not for therapeutic or personal use.
Dexfenfluramine - Wikipedia
External links * Drug description. * Dexfenfluramine hydrochloride. * Questions and Answers about Withdrawal of Fenfluramine (Pond...
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6 Sept 2012 — Dexfenfluramine, also known as redux, belongs to the class of organic compounds known as amphetamines and derivatives. These are o...
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Dexfenfluramine hydrochloride (CAS 3239-45-0)
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14 Apr 2024 — Dexfenfluramine is a serotonergic anorectic drug, primarily known for its role in appetite suppression. It is the d-enantiomer of fenfluramine ...Read more
21 Dec 2022 — CAS No. 3239-44-9. Chemical Name: (+)-FENFLURAMINE HYDROCHLORIDE. Synonyms: redux;adifax;d-fenfluramine;DEXFENFLURAMINE;(s)-fenfluramine;(s ...Read more
Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States ...Read more
CAS NO. 3239-44-9 | (+)-FENFLURAMINE HYDROCHLORIDE
View and buy high quality Dexfenfluramine hydrochloride from Tocris Bioscience. 5-HT reuptake inhibitor; also stimulates 5-HT release.
Missing: (Redux) 3239-44-9
Dexfenfluramine hydrochloride, CAS No. 3239-45-0
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Empirical formula C12H16F3N·HCl. Molar mass (M) 267,72 g/mol. Melting point (mp) 161 °C Storage temp. -20 °C Transport temp. ambient temp. ADR 6.1 IIIRead more
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Missing: (Redux) 3239-44-9
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Dexfenfluramine hydrochloride (CAS 3239-45-0)
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