Description

Buy N-Ethylhexedrone Cas 802857-66-5

N-Ethylhexedrone (also known as α-ethylaminohexiophenone, α-EAHP, α-ethylamino-caprophenone, N-ethylnorhexedrone, Ethylnorhexedrone, Norhexedrone, Ethylhexedrone, hexen, and NEH) is a stimulant of the cathinone class^[2][3] that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI) with IC₅₀ inhibition values of 0.0978 and 0.0467 μM, respectively (97 nM and 46 nM).^[4] N-Ethylhexedrone was first mentioned in a series of patents by Boehringer Ingelheim in the 1960s^[5] which led to the development of the better-known drug methylenedioxypyrovalerone (MDPV).^{[6][failed verification]} Since the mid-2010s, N-ethylhexedrone has been sold online as a designer drug.^[7][8][9] In 2018, N-ethylhexedrone was the second most common drug of the cathinone class to be identified in Drug Enforcement Administration seizures.^[10] N-Ethylhexedrone was first synthesized by Boehringer Ingelheim in 1964.^[11] It appears to have emerged on the online research chemical market in late 2015.^[12] It is an example of a novel psychoactive substance specifically chosen to mimic the features of prohibited substances and bypass drug laws. It is one of a number of substances collectively referred to as "bath salts".^[13] User reports characterize N-ethylhexedrone as having euphoric stimulant effects comparable to those of crack cocaine and α-PVP-type compounds, particularly when they are insufflated or vaporized. Like other substituted cathinones, N-ethylhexedrone has gained notoriety for its association with compulsive redosing and addictive behaviors when abused. N-Ethylhexedrone was patented by the German pharmaceutical company Boehringer Ingelheim in 1964 as a potential anorexigenic agent. The patent describes its synthesis together with other derivatives of aminoketone.^[11] The substance spread remarkably quickly in the NPS market in different European countries.^[11] It was first identified in a sample from the Belgian Customs laboratory which was received at the JRC in November 2015. In January 2016, it was identified at the JRC in a sample provided by French Customs. Subsequently, in February 2016, the EMCDDA received notifications of the identification of this substance from other countries, such as Sweden, The Netherlands, France, Belgium and Slovenia.^[14] In 2017 it was the most frequent seized cathinone in the EU, Norway and Turkey.^[15] In 2018, it was the most commonly identified cathinone after pentylone in Drug Enforcement Administration seizures.^[13]