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Buy Pentedrone Cas 879722-57-3
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Buy Pentedrone Cas 879722-57-3

Description

Buy Pentedrone Cas 879722-57-3

Pentedrone (also known as α-methylaminovalerophenone) is a stimulant of the cathinone class that has been sold as a designer drug and has been found since 2010 as an ingredient in a number of "bath salt" mixes sold as legal highs.[3][4][5][6][7][8][9]

Pharmacology

Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor (NDRI) without inducing monoamine release, a similar mechanism of action to methylphenidate.[10][11] Its IC50Tooltip half-maximal inhibitory concentration values for inhibition of monoamine reuptake have been reported to be 610 nM for norepinephrine, 2,500 μM for dopamine, and 135,000 μM for serotonin.[10] In rodents, pentedrone has been found to produce conditioned place preference (CPP), to be self-administered, and to dose-dependently stimulate locomotor activity.[11] Hence, pentedrone shows psychostimulant-like and reinforcing effects in animals.[11]

Side effects

Pentedrone has been linked to at least one death where it was combined with α-PVP and caused heart failure.[12]

Detection

A forensic standard of pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[13]
On January 28, 2014, the DEA listed it, along with nine other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.[14] Pentedrone is an Anlage II controlled drug in Germany. As of October 2015 Pentedrone is a controlled substance in China.[15] Pentedrone is banned in the Czech Republic.[16] Pentedrone is banned in the Slovak Republic.[17]

See also

  • 4-Methylpentedrone
  • Buphedrone
  • MDPV
  • Methcathinone
  • Pentylone
  • Phenylpropylaminopentane
  • Substituted cathinone
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