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Buy Pholedrine Cas 370-14-9
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Buy Pholedrine Cas 370-14-9

Description

Buy Pholedrine Cas 370-14-9

Pholedrine, also known as 4-hydroxy-N-methylamphetamine and sold under the brand names ParedrinolPulsotyl, and Veritol among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil.[1][2][3] It can be used to diagnose Horner's syndrome.[3] In 2004, it remained marketed only in Germany.[1][needs update]

Pharmacology

Pharmacodynamics

Pholedrine is described as a sympathomimeticantihypotensive, and ephedrine-like agent.[4][1][5]

Chemistry

Pholedrine, also known as 4-hydroxy-N-methylamphetamine, is a substituted phenethylamine and amphetamine derivative.[4][1] It is structurally related to methamphetamine (N-methylamphetamine), norpholedrine (4-hydroxyamphetamine), oxilofrine (4,β-dihydroxy-N-methylamphetamine), and tyramine (4-hydroxyphenethylamine). It is used pharmaceutically as the sulfate salt.[1][4] The predicted log P of pholedrine ranges from 1.12 to 1.7.[2][6][7]

History

Pholedrine was synthesized by 1951.[4]

Society and culture

Names

Pholedrine is the generic name of the drug and its INNTooltip International Nonproprietary NameBANTooltip British Approved Name, and DCFTooltip Dénomination Commune Française, while foledrina is its DCITTooltip Denominazione Comune Italiana.[4][1][5] The drug has been sold under brand names including Pholedrin LiquidumPholedrin-Longo-IsisPresoitanVeritain, and Veritol among others.[4][1]

Other drugs

Pholedrine (4-hydroxymethamphetamine) is also a major metabolite of methamphetamine.

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Pholedrine is an Autonomic Agent. It is a a sympathomimetic vasoconstrictive drug which has been used to treat chronic hypotension.

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