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Buy Phenylpropanolamine (PPA) Cas 14838-15-4

Phenylpropanolamine (PPA), sold under many brand names, is a sympathomimetic agent used as a decongestant and appetite suppressant.^{[7][8][9][10]} It was once common in prescription and over-the-counter cough and cold preparations. The medication is taken orally.^[2][11] Side effects of phenylpropanolamine include increased heart rate and blood pressure.^{[12][13][14][11]} Rarely, PPA has been associated with hemorrhagic stroke.^[10][15][12] PPA acts as a norepinephrine releasing agent, indirectly activating adrenergic receptors.^[16][17][18] As such, it is an indirectly acting sympathomimetic.^{[16][17][18][9]} It was once thought to act as a sympathomimetic with additional direct agonist action on adrenergic receptors, but this proved wrong.^[16][17][18] Chemically, phenylpropanolamine is a substituted amphetamine and is closely related to ephedrine, pseudoephedrine, amphetamine, and cathinone.^{[19][20][21][10]} It is usually a racemic mixture of the (1R,2S)- and (1S,2R)-enantiomers of β-hydroxyamphetamine and is also known as dl-norephedrine.^[20][7][8] Phenylpropanolamine was first synthesized around 1910 and its effects on blood pressure were characterized around 1930.^[20][10] It was introduced as medicine by the 1930s.^[22][10] It was withdrawn from many markets starting in 2000 after learning that it was associated with increased risk of hemorrhagic stroke.^[22][10] It was previously available both over-the-counter and by prescription.^{[22][23][24][25]} Phenylpropanolamine is available for both human and/or veterinary use in some countries.^[23] Phenylpropanolamine is used as a decongestant to treat nasal congestion.^[12][13] It has also been used to suppress appetite and promote weight loss in the treatment of obesity and has shown effectiveness for this indication.^[26][27][28] Phenylpropanolamine was previously available in the United States over-the-counter and in certain combination drug forms by prescription.^[24][25] One such example of the latter was a combination of phenylpropanolamine and chlorpheniramine, which dually contained decongestant and antihistamine effects, marketed by Tutag as 'Vernate'. These forms have all been discontinued in the U.S.,^[24][25][23] although phenylpropanolamine remains available in some countries.^[23] Phenylpropanolamine produces sympathomimetic effects and can cause side effects such as increased heart rate and blood pressure.^{[12][13][14][11]} It has been associated rarely with incidence of hemorrhagic stroke.^[22][15][12] Certain drugs increase the chances of déjà vu occurring in the user, resulting in a strong sensation that an event or experience currently being experienced has already been experienced in the past. Some pharmaceutical drugs, when taken together, have also been implicated in the cause of déjà vu.^[29] The Journal of Clinical Neuroscience reported the case of an otherwise healthy male who started experiencing intense and recurrent sensations of déjà vu upon taking the drugs amantadine and phenylpropanolamine together to relieve flu symptoms.^[29] He found the experience so interesting that he completed the full course of his treatment and reported it to the psychologists to write up as a case study. Because of the dopaminergic action of the drugs and previous findings from electrode stimulation of the brain,^[30] it was speculated that déjà vu occurs as a result of hyperdopaminergic action in the mesial temporal areas of the brain. There has been very little research on drug interactions with phenylpropanolamine.^[2] In one study, phenylpropanolamine taken with caffeine was found to quadruple caffeine levels.^[2] In another study, phenylpropanolamine reduced theophylline clearance by 50%.^[2] Phenylpropanolamine acts primarily as a selective norepinephrine releasing agent.^[18] It also acts as a dopamine releasing agent with around 10-fold lower potency.^[18] The stereoisomers of the drug have only weak or negligible affinity for α- and β-adrenergic receptors.^[18]

Monoamine release by phenylpropanolamine and related agents (EC₅₀Tooltip half maximal effective concentration, nM)

Compound	NETooltip Norepinephrine	DATooltip Dopamine	5-HTTooltip Serotonin	Ref
Dextroamphetamine (S(+)-amphetamine)	6.6–7.2	5.8–24.8	698–1,765	[31][32]
S(–)-Cathinone	12.4	18.5	2,366	[18]
Ephedrine ((–)-ephedrine)	43.1–72.4	236–1,350	>10,000	[31]
(+)-Ephedrine	218	2,104	>10,000	[31][18]
Dextromethamphetamine (S(+)-methamphetamine)	12.3–13.8	8.5–24.5	736–1,292	[31][33]
Levomethamphetamine (R(–)-methamphetamine)	28.5	416	4,640	[31]
(+)-Phenylpropanolamine ((+)-norephedrine)	42.1	302	>10,000	[18]
(–)-Phenylpropanolamine ((–)-norephedrine)	137	1,371	>10,000	[18]
Cathine ((+)-norpseudoephedrine)	15.0	68.3	>10,000	[18]
(–)-Norpseudoephedrine	30.1	294	>10,000	[18]
(–)-Pseudoephedrine	4,092	9,125	>10,000	[18]
Pseudoephedrine ((+)-pseudoephedrine)	224	1,988	>10,000	[18]
Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs: [34][16] AI Overview Phenylpropanolamine (PPA), identified by CAS number 14838-15-4, is a substance that has been subject to significant regulatory actions and restrictions globally.   Regulatory and Health Information: In the United States and several other countries, the sale of Phenylpropanolamine for human use has been withdrawn or heavily restricted. These actions were primarily driven by medical research indicating an increased risk of hemorrhagic stroke (bleeding in the brain) associated with its use in appetite suppressants and cough or cold remedies.  Controlled Substance Status: Due to its chemical structure, PPA is also classified as a regulated precursor in many regions. For example, in the United States, it is listed as a DEA List I chemical. This means its distribution is strictly monitored, and it is generally only available to registered industrial, pharmaceutical, or research institutions that provide proper documentation and legitimate end-use certifications.  Information regarding the commercial acquisition of this substance for personal use cannot be provided, as doing so may involve bypassing legal safety protocols and regulatory requirements. Phenylpropanolamine | CAS No- 14838-15-4 | NA Buy high quality Phenylpropanolamine with CAS No - 14838-15-4 from Chemicea Pharma. Chemicea Pharma is one of the leading manufact... Chemicea Pharmaceuticals CAS 154-41-6: Phenylpropanolamine hydrochloride However, due to safety concerns, particularly regarding its ( Phenylpropanolamine hydrochloride ) association with increased risk ... CymitQuimica What is the mechanism of Phenylpropanol? 17 Jul 2024 — Due to these potential risks, phenylpropanol has been subject to regulatory scrutiny and, in some regions, its use has been restri... Patsnap Synapse Show all Show more Phenylpropanolamine | 14838-15-4 ChemicalBook https://www.chemicalbook.com › ... › CAS DataBase List Phenylpropanolamine (CAS 14838-15-4) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight ... US$430.00 Phenylpropanolamine | CAS No- 14838-15-4 | NA Chemicea Pharmaceuticals https://chemicea.com › product › phenylpropanolamine Buy high quality Phenylpropanolamine with CAS No - 14838-15-4 from Chemicea Pharma. Chemicea Pharma is one of the leading manufacturer and exporter of ...Read more Missing: (PPA) ‎| Show results with: (PPA) People also ask Why is phenylpropanolamine banned? How to buy phenylpropanolamine? What is the drug phenylpropanolamine used for? What are the long term side effects of phenylpropanolamine? Phenylpropanolamine (Cas 14838-15-4) - Parchem parchem.com https://parchem.com › chemical-supplier-distributor › p... Parchem supplies Phenylpropanolamine and a range of specialty chemicals worldwide, CAS# 14838-15-4. Missing: (PPA) ‎| Show results with: (PPA) 14838-15-4 | (1S,2R)-2-amino-1-phenylpropan-1-ol Anax Laboratories https://www.anaxlab.com › product › 14838-15-4-1s2r... Buy high quality 14838-15-4 - (1S,2R)-2-amino-1-phenylpropan-1-ol with Purity >96% at Anax Laboratories. Missing: Phenylpropanolamine ‎(PPA) 2-Amino-1-phenyl-propan-1-ol | 48115-38-4 Benchchem https://www.benchchem.com › product Benchchem offers qualified products for 2-Amino-1-phenyl-propan-1-ol (CAS No. 48115-38-4), please inquire us for more detail. Phenylpropanolamine API price and transactions Pharmaoffer.com https://pharmaoffer.com › api-excipient-supplier › phen... CAS 14838-15-4 | Phenylpropanolamine API price index | 199 transactions | Latest pricing charts, historical trade data and insights. Buy Norephedrine | 14838-15-4 Smolecule https://www.smolecule.com › products Norephedrine, commonly known as norepinephrine, is a catecholamine and a phenethylamine that serves as both a neurotransmitter and a hormone. Phenylpropanolamine | C9H13NO | CID 10297 - PubChem National Institutes of Health (.gov) https://pubchem.ncbi.nlm.nih.gov › compound › Pheny... Phenylpropanolamine (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. Phenylpropanolamine is found ...Read more Phenylpropanolamine Wikipedia https://en.wikipedia.org › wiki › Phenylpropanolamine Phenylpropanolamine (PPA), sold under many brand names, is a sympathomimetic agent used as a decongestant and appetite suppressant.Read more Side effects Pharmacology Chemistry Society and culture Phenylpropanolamine: Uses, Interactions, Mechanism of ... DrugBank https://go.drugbank.com › drugs 13 Jun 2005 — Pharmacodynamics. Phenylpropanolamine (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion.Read more