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Buy 3-4-Methylenedioxyamphetamine (MDA) Cas 4764-17-4

3,4-Methylenedioxyamphetamine (MDA) is an entactogen, stimulant, and psychedelic drug of the amphetamine and MDxx families that is encountered mainly as a recreational drug.^[4][5][6] It is usually taken orally.^[4][6] In terms of its pharmacology, MDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) and a serotonin 5-HT₂ receptor agonist, including of the serotonin 5-HT_2A receptor.^[4] It has a duration of 5 to 8 hours or around 6 hours typically.^[4][3][2] MDA has a long history of psychotherapeutic and recreational use that predates that of MDMA, dating back to at least the mid-1960s.^[4][7][5] It has been described as the first entactogen.^[3] MDA has also been described as probably the most popular analogue of MDMA.^[7] In most countries, the drug is a controlled substance and its possession and sale are illegal. MDA is bought, sold, and used as a recreational drug due to its enhancement of mood and empathy.^[8] It produces MDMA-like effects, including entactogenic and stimulant effects, as well as mild psychedelic effects.^{[3][9][10][2]} The dose range of MDA given in Alexander Shulgin's book PiHKAL (Phenethylamines I Have Known and Loved) and other sources is 80 to 160 mg.^[6][4] A wider recreational dose range for MDA of 20 to 200 mg or more, with a typical dose estimate of 90 mg, has also been reported.^[11] The dose range of MDA is very similar to that of MDMA.^{[6][4][11][3]} The effects of MDA include euphoria, empathy, emotional amplification, relaxation, feeling at peace with the world, increased introspection, self-awareness, and acceptance, authenticity, clarity of thought, a desire to communicate with others and relate personal issues, and emotional bonding with others.^[4][12][13] These effects led to MDA being called the "love drug" or "hug drug".^[12][6] MDA also produces mild psychedelic effects, including brightened colors, closed-eye visuals or complex mental imagery, synaesthesia, and rarely mild hallucinations.^[4][3] It does not produce profound sensory disruption or overt hallucinations.^[12][13] In any case, the drug has still been found to produce mystical or spiritual experiences.^[9][3] MDA shares most of MDMA's qualitative and emotional effects, including entactogenic and stimulant effects.^[4][13][3] However, it has been said to be slightly less stimulating than MDMA.^[4][3] Conversely, a clinical study found that it was more stimulating than MDMA.^[2] In addition, MDA's hallucinogenic effects are much greater than those of MDMA, although still less than those of classical psychedelics like psilocybin.^{[4][12][3][2]} Another difference between the two drugs is that MDA appears to produce a more introverted and emotionally intense prosocial state, while MDMA encourages a more extroverted and gregarious prosocial state.^[3] MDA produces more negative "bad drug effects" and fear than MDMA.^[2] Besides its psychoactive effects, MDA produces sympathomimetic effects such as increased heart rate and blood pressure, among other physiological effects.^[7][13][3] In terms of the individual enantiomers of MDA, (R)-MDA produces psychedelic effects and some entactogenic effects, while (S)-MDA is non-hallucinogenic, produces similar entactogenic effects as the racemate, and has considerable stimulant effects.^[12][13][6] High doses of enantiopure (R)-MDA, in the range of 120 to 200 mg, are described as closely resembling the effects of LSD, for instance doses of 200 to 400 μg.^[13][14] Enantiopure (R)-MDA at high doses produces more robust psychedelic effects than typical doses of racemic MDA.^[13][14][6] The duration of MDA is about 5 to 8 hours and is about 2 hours longer than that of MDMA (3–6 hours).^[4][3][2] Shulgin originally gave a duration of MDA of 8 to 12 hours in PiHKAL, but he later revised this down to only 3 to 6 hours.^[6] Modern clinical studies have given an average duration of 6 to 8 hours with a range of 0.9 to 10 hours.^[3][2] The drug's onset is 0.7 hours (range 0.3 to 1.1 hours) and its time to peak effects is 2.0 hours (range 1.0 to 3.5 hours).^[2]