Description

Buy MMDA-2 Cas 23693-18-7

MMDA-2, also known as 2-methoxy-4,5-methylenedioxyamphetamine or as 6-methoxy-MDA, is a psychedelic drug of the phenethylamine, amphetamine, and MDxx families.^[1][2] It is the 6-methoxy derivative of MDA and is a positional isomer of MMDA (5-methoxy-MDA).^[1][2] In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MMDA-2's dose as 25 to 50 mg orally and its duration as 8 to 12 hours.^[1][2] The effects of MMDA-2 have been reported to include enhanced awareness, empathy, and visual facilitation and distortion, as well as some side effects like gastrointestinal upset and appetite loss.^[1] Shlgin states that MMDA-2 at a dose of 30 mg orally is very similar to MDA at a dose of 80 mg orally, and also remarks that it would be impossible for anyone to have a bad experience on the drug at that dose.^[1] MMDA-2 is approximately 4- or 5-fold more potent than MMDA, which has a listed dose range of 100 to 250 mg orally.^[1] MMDA-2 is a moderately potent serotonin receptor agonist in the rat stomach fundus assay (A₂ = 224 nM).^[3] These serotonin receptors may correspond specifically to the serotonin 5-HT_2B receptor.^[4][5] It has been found that MMDA-2, unlike MMDA but similarly to 6-methyl-MDA, is very weak or negligible at inducing the release of serotonin or dopamine in vitro.^[6] Accordingly, it does not produce amphetamine-like responses in animals in drug discrimination studies.^[7] Instead, MMDA-2 is likely to act as a pure serotonin 5-HT₂ receptor agonist similarly to the DOx series of compounds, with activation of the serotonin 5-HT_2A receptor believed to be responsible for its psychedelic effects.^[8] The chemical synthesis of MMDA-2 has been described.^[1]